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Compare Flonase vs. Claritin for Allergy Relief

When it comes to managing your allergy symptoms, there are many over-the-counter (OTC) medicines to choose from. But how do you know which is right for you? Medicines like Claritin® are single-ingredient oral antihistamines that do not treat nasal congestion. FLONASE nasal sprays work differently to relieve nasal congestion,* plus sneezing, runny nose, itchy nose, and itchy, watery eyes.


For years the go-to option for allergy relief was an antihistamine, usually in the form of a pill. But antihistamines only block histamine, just 1 of many allergic substances your immune system releases when you're exposed to an allergen.1 FLONASE helps block 6 key allergic substances, not just histamine.** 

Here’s a look at how FLONASE nasal sprays compare to single-ingredient oral antihistamines like Claritin®.


FLONASE Nasal Sprays
Single-Ingredient Claritin ®

Relieves nasal congestion*

Helps block 6 key allergic substances**

Relieves itchy nose, runny nose, and sneezing

Available without a prescription

Indicated to relieve itchy, watery eyes†

Applied directly at the source, in the nose

Please see specific products for full labeling information. Use only as directed.

Click below to learn more about FLONASE nasal sprays and discover which is right for you. 

Flonase Beauty Portfolio

*vs single-ingredient antihistamines that do not treat nasal congestion.

FLONASE SENSIMIST is indicated for itchy, watery eyes in adults and children 12 years of age and older. See product pages for full information.

**Mechanism vs most over-the-counter (OTC) allergy pills. FLONASE nasal sprays act on multiple inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines, and leukotrienes). The exact number and precise mechanism are unknown.

Claritin® is a registered trademark of Bayer. 


  1. AAFA. Rhinitis and Sinusitis. Accessed August 1, 2018.