Compare Flonase vs. Zyrtec for Allergy Relief

Not all over-the-counter (OTC) allergy medicines are created equal. Single-ingredient oral antihistamines don't relieve nasal congestion, and some, like Zyrtec, may even cause drowsiness. FLONASE nasal sprays are non-drowsy, anti-inflammatory allergy relief nasal sprays that provide more complete relief* than a single-ingredient antihistamine. Here’s how FLONASE stacks up against oral antihistamines, like Zyrtec.

FLONASE DOES MORE

Antihistamines only block histamine—just 1 of the many allergic substances your immune system releases when you’re exposed to an allergen.1 However, FLONASE works differently to help block 6 key allergic substances,** including histamine.

NON-DROWSY ALLERGY RELIEF

A known side effect of certain antihistamines like Zyrtec is drowsiness. This may affect your ability to perform everyday tasks, like driving or operating heavy machinery.2 Not only are FLONASE nasal sprays non-drowsy—they also provide more complete relief than most allergy pills.*

*vs single­-ingredient antihistamines that do not treat nasal congestion.
**Mechanism vs most over-the-counter (OTC) allergy pills. FLONASE nasal sprays act on multiple inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines, and leukotrienes). The exact number and precise mechanism are unknown.